Crystal Size Control in a Continuous Tubular Crystallizer
Category
Published on CMKC
Abstract
This paper describes a simple model-free (i.e., empirical) control strategy for crystal size tuning in a continuously operated tubular crystallizer. The crystallizer is designed for a seeded cooling crystallization process and acetylsalicylic acid crystallization from an ethanol solution was used as model system. Using a crystal size distribution (CSD) analyzer and minor initial studies, we developed a feedback controller that accurately tuned the mean crystal size within the range of 90–140 μm. In addition, we created a cleaning concept for long-term runs based on a consistency study, which demonstrated that the CSD of the products remained robust when process settings were kept constant. Sufficiently small and uniform seed crystals were generated via ultrasound irradiation.
Journal
DOI
Type of publication
Affiliations
- Research Center Pharmaceutical Engineering GmbH (RCPE)
Article Classification
Classification Areas
- Control