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Effects of rotation rate, mixing angle, and cohesion in two continuous powder mixers-A statistical approach

By Portillo, PM; Ierapetritou, MG; Muzzio, FJ

Published on CMKC

Abstract

In this paper we examine the effect of rotation rate, mixing angle, and cohesion on the powder residence time and the content uniformity of the blend exiting from two continuous powder mixers. In addition, differences in mixing performance between the two blenders are examined. Analysis of variance is used to determine significance of main effects and their interactions. The results show that the effect of powder cohesion is scale-dependent, having a significant effect in the larger mixer. The overall rotation rate was the least influential parameter in terms of content uniformity. The residence time is significantly affected by both rotation rate and mixing angle.

Journal

Powder Technology. Volume 194, 2009, 217-227

DOI

10.1016/j.powtec.2009.04.010

Type of publication

Peer-reviewed journal

Affiliations

  • Rutgers State University

Article Classification

Research article

Classification Areas

  • Oral solid dose

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