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Ensuring tablet quality via model-based control of a continuous direct compaction process

By Kirchengast, M; Celikovic, SRehrl, J; Sacher, S; Kruisz, J; Khinast, J; Horn, M

Published on CMKC

Abstract

Switching from batch to continuous pharmaceutical production offers several advantages, such as an increased productivity, a steady product quality, and decreased costs. This paper presents a control strategy for direct compaction on a continuous tablet production line consisting of two feeders, one blender, and a tablet press (TP). A data-driven, linear modeling approach is applied in order to develop a Smith predictor for active pharmaceutical ingredient concentration control and a model predictive controller responsible for the TP hopper level. Additionally, in case of severe concentration variations out-of-specification material can be discarded before it enters the TP. The effectiveness of the control concept is tested not only in simulations but also by implementing it on a real pilot plant.

Journal

International Journal of Pharmaceutics. Volume 567, 2019, 118457

DOI

10.1016/j.ijpharm.2019.118457

Type of publication

Peer-reviewed journal

Affiliations

  • Graz University of Technology
  • Research Center Pharmaceutical Engineering GmbH

Article Classification

Research Article

Classification Areas

  • Oral solid dose
  • Process Control and modeling
  • PAT

Tags