Ensuring tablet quality via model-based control of a continuous direct compaction process
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Abstract
Switching from batch to continuous pharmaceutical production offers several advantages, such as an increased productivity, a steady product quality, and decreased costs. This paper presents a control strategy for direct compaction on a continuous tablet production line consisting of two feeders, one blender, and a tablet press (TP). A data-driven, linear modeling approach is applied in order to develop a Smith predictor for active pharmaceutical ingredient concentration control and a model predictive controller responsible for the TP hopper level. Additionally, in case of severe concentration variations out-of-specification material can be discarded before it enters the TP. The effectiveness of the control concept is tested not only in simulations but also by implementing it on a real pilot plant.
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Affiliations
- Graz University of Technology
- Research Center Pharmaceutical Engineering GmbH
Article Classification
Classification Areas
- Oral solid dose
- Process Control and modeling
- PAT