Evolution of flow-oriented design strategies in the continuous preparation of pharmaceuticals

Fulop, Z; Szemesi, PBana, P; Eles, J; Greiner, I

Evolution of flow-oriented design strategies in the continuous preparation of pharmaceuticals

By Fulop, Z; Szemesi, PBana, P; Eles, J; Greiner, I

View Resource (DOI)

Published on

09 Jun 2023

Abstract

The dynamic progress in the multi-step continuous-flow synthesis of active pharmaceutical ingredients is part of the current industrial revolution. The recently implemented examples are the forerunners of safer and more sustainable pharmaceutical manufacturing. These systems utilize interconnected flow apparatuses, integrated with in-line work-up, purification and analysis. Challenging targets call for customized, flow-oriented designs to establish novel, telescoped continuous-flow sequences. In this review we focus on these efforts towards the development of uninterrupted continuous-flow systems.

Journal

Reaction Chemistry & Engineering. Volume 5, 2020, 1527-1555

DOI

10.1039/d0re00273a

Type of publication

Peer-reviewed journal

Affiliations

Budapest University of Technology and Economics
Gedeon Richter Plc

Article Classification

Review article

Classification Areas

API