n the work reported here, a substrates adoption methodology for a series of similar substrates has been developed as part of a retrofit strategy. The objective is to achieve “fast, flexible and future” pharmaceutical production processes by adapting a generic modular process-plant template. Application of the methodology is illustrated through a case study from the pharmaceutical industry. Use of computer-aided models, methods and tools as part of the methodology is also highlighted.

• Rutgers, The State University of New Jersey

• Oral doses
• Modeling

1. fast
2. flexible
3. modeling
4. N/A
5. Oral doses
6. Research Article
7. retrofit strategy
8. substrates adoption methodology