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Prepare for an exciting September! Each week, we'll examine the latest trends in PAT, offering fresh insights straight from recent conferences. Your perspective matters, so we encourage you to share your thoughts as well. Stay informed, stay engaged, and let's explore these cutting-edge developments together. https://bit.ly/3Xw0X7k
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  1. Liquid API feeding in pharmaceutical HME: Novel options in solid dosage manufacturing

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    18 Jan 2024 | Peer-reviewed journal | Contributor(s): Simone Eder, Aygün Doğan, Johannes Khinast, Stephan Sacher, Martin Spoerk, Lisa Kuchler

    Hot melt extrusion (HME) is a common unit operation. It is broadly applicable in the pharmaceutical industry and can be implemented in a continuous manufacturing line. However, the conventional way of active pharmaceutical ingredient (API) feeding with a pre-blend consisting of a powdered API...

  2. USP-ID

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    04 Jan 2024 | Website | Contributor(s): Molly Ferns

    USP-ID, delivered by Mestrelab Research, is a one-click, automated software solution for identifying, quantifying and labelling a broad range of chemical components in both simple solutions and complex mixtures by qNMR.

  3. Quality & Regulatory Solutions for PAT in Continuous Manufacturing

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    04 Jan 2024 | Magazine | Contributor(s): Gabriella Dahlgren, Kevin A. Macias, Antonio R. Moreira, Duncan R. Thompson, Christoph Herwig, Robert Dream

    Process analytical technology (PAT) is perceived as the main enabler for a robust control strategy with continuous manufacturing (CM) because process analytical technology can aid in implementing continuous manufacturing throughout the entire life cycle. This article discusses quality and...

  4. Batch vs. continuous direct compression – a comparison of material processability and final tablet quality

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    03 Jan 2024 | Peer-reviewed journal | Contributor(s): S. Fathollahi, D. Vanderroost, T. Roelofs, B.H.J. Dickhoff, C. Vervaet, V. Vanhoorne, B. Bekaert, P.H.M. Janssen

    In this study, an in-depth comparison was made between batch and continuous direct compression using similar compression set-ups. The overall material processability and final tablet quality were compared and evaluated. Correlations between material properties, process parameters and final...

  5. E-factor analysis of a pilot plant for end-to-end integrated continuous manufacturing (ICM) of pharmaceuticals

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    06 Dec 2023 | Peer-reviewed journal | Contributor(s): Stephen C. Born, Wei Wu, Khrystyna Shvedova, Ridade Sayin, Bhakti S. Halkude, Federica Casati, Anjana Ramnath, Paul Hermant, Bayan Takizawa, Thomas F. O'Connor, Xiaochuan Yang, Sukumar Ramanujamd, Salvatore Mascia, Christopher J. Testa, Chuntian Hu

    Most drugs are still manufactured by time-intensive and cost-inefficient batch processes; however, the pharmaceutical industry is undergoing a transition to continuous processes to benefit from the reduced lead time, cost, and footprint and improved quality associated with this new methodology....

  6. Sustainability case studies on the use of continuous manufacturing in pharmaceutical production

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    06 Dec 2023 | Peer-reviewed journal | Contributor(s): Mark S. Kerr, Kevin P. Cole

    Continuous processing is now commonly used in the manufacturing of fine chemicals including agrochemicals and pharmaceuticals. Datasets are now available, including some on environmental sustainability aspects, that enable more direct comparison between related batch and flow processes....

  7. MOOC 1 Introduction to Continuous Manufacturing

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  8. Residence Time Distribution - Test Example

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  9. MOOC I - Batch vs. Continuous Manufacturing: Revolutionizing Medicine Production

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  10. MOOC I Introduction - The Advantages and Challenges of Continuous Manufacturing in Pharmaceuticals

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

    In this video, we start exploring the world of continuous manufacturing in the pharmaceutical industry. Discover how this innovative technology is revolutionizing the production of medicines, its advantages over traditional batch manufacturing, and the challenges it presents. Join us as we delve...

  11. MOOC I Blending - Flow and Mixing Regime

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  12. MOOC I Feeding - Refill Strategy

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  13. MOOC I Blending Basics

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  14. MOOC I Continuous Blender Types

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  15. MOOC I Feeding - Twin Screw Feeder

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  16. MOOC I Feeding - Disturbances

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  17. MOOC I Continuous Blend Analysis

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  18. MOOC I Control Strategy - Model-Based Control

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  19. MOOC I Control Strategy - Process Control

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  20. MOOC I Control Strategy - Examples

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  21. MOOC I Control Strategy - Introduction

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  22. MOOC I Control Strategy - Quality Control

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  23. MOOC 1 Tracer Test for RTD Measurement

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  24. MOOC 1 Residence Time Distribution

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    29 Nov 2023 | Teaching Materials | Contributor(s): RCPE

  25. Continuous Manufacturing to Improve Pharmaceutical Quality: Research Examples and Opportunities

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    20 Nov 2023 | Workshop | Contributor(s): Geng Tian

    Continuous manufacturing (CM) of drug substances and drug productsProcess modeling and simulation (M&S) for CM at FDACM research highlightsOpportunities of CM for generic drug productsPharmaceutical Quality Symposium 2023: Quality, Supply Chain & Advanced Manufacturing -...