An expeditious synthesis of imatinib and analogues utilising flow chemistry methods
Contributor(s):: Hopkin, Mark D., Baxendale, Ian R., Ley, Steven V.
A flow-based route to imatinib, the API of Gleevec, was developed and the general procedure then used to generate a number of analogues which were screened for biological activity against Abl1. The flow synthesis required minimal manual intervention and was achieved despite the poor solubility of...