An expeditious synthesis of imatinib and analogues utilising flow chemistry methods
Category
Published on CMKC
Abstract
A flow-based route to imatinib, the API of Gleevec, was developed and the general procedure then used to generate a number of analogues which were screened for biological activity against Abl1. The flow synthesis required minimal manual intervention and was achieved despite the poor solubility of many of the reaction components.
Journal
Organic & Biomolecular Chemistry. Volume 11, 2013, 1822-39
DOI
10.1039/C2OB27002A
Type of publication
Peer-reviewed journal
Affiliations
- University of Cambridge
- Durham University
Article Classification
Research article
Classification Areas
- API