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3.12.148.180

An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

By Hopkin, Mark D.; Baxendale, Ian R.; Ley, Steven V.

View Resource (DOI)

Category

Peer-reviewed journal

Published on

Abstract

A flow-based route to imatinib, the API of Gleevec, was developed and the general procedure then used to generate a number of analogues which were screened for biological activity against Abl1. The flow synthesis required minimal manual intervention and was achieved despite the poor solubility of many of the reaction components.

Journal

Organic & Biomolecular Chemistry. Volume 11, 2013, 1822-39

DOI

10.1039/C2OB27002A

Type of publication

Peer-reviewed journal

Affiliations

  • University of Cambridge
  • Durham University

Article Classification

Research article

Classification Areas

  • API

Tags

  1. Abl1
  2. analogues
  3. API
  4. continuous synthesis
  5. flow synthesis
  6. Gleevec
  7. imatinib
  8. Research Article