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The Use of Cooling Crystallization in an Ionic Liquid System for the Purification of Pharmaceuticals
Contributor(s):: Weber, CC, Kulkarni, SAKunov-Kruse, AJ, Rogers, RD, Myerson, AS
The application of ionic liquids (ILs) as solvents is frequently discussed in the context of their tunability, with the potential to tailor the solvent system uniquely to the process being investigated. Instead, here we study the potential for a single IL, 1-ethyl-3-methylimidazohum...
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Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes
Contributor(s):: Thomas, LH, Wales, C, Wilson, CC
A transferable, simple, method for producing previously elusive and novel polymorphic forms of important active pharmaceutical ingredients (APIs; paracetamol (acetaminophen), piroxicam and piracetam) is demonstrated. Nitrogen heterocyclic co-molecules are employed to influence the self-assembly...
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Process design applied to optimise a directly compressible powder produced via a continuous manufacturing process
Contributor(s):: Gonnissen, Y., Goncalves, S. I. V., De Geest, B. G., Remon, J. P., Vervaet, C.
Manufacturing of 'ready-to-compress' powder mixtures for direct compression was performed by spray drying, without granulation, milling and/or blending steps in between spray drying and compaction. Powder mixtures containing acetaminophen, mannitol, erythritol, maltodextrin, crospovidone,...
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Manipulation of ionic liquid anion-solute-antisolvent interactions for the purification of acetaminophen
Contributor(s):: Weber, CC, Kunov-Kruse, AJRogers, RD, Myerson, AS
Hydrogen bond donating cosolvents have been shown to significantly reduce the solubility of acetaminophen (AAP) in ionic liquids containing the acetate anion. Reduced solubility arises from competition for solvation by the acetate anion and can be used for the design of advanced separation...
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Impact of surface roughness of pre-treated punches and powder properties on prevention of sticking during pharmaceutical tableting
Contributor(s):: Takeuchi, Y, Murase, YTahara, K, Takeuchi, H
In the present study, surface-modified punches with different roughness were evaluated for their ability to prevent sticking during pharmaceutical tableting using a single punch machine. The surface roughness of the punch faces was assessed using a laser microscope. Acetaminophen and ibuprofen...
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Feedrate deviations caused by hopper refill of loss-in-weight feeders
Contributor(s):: William E. Engisch, Fernando J. Muzzio
Continuous powder processing requires accurate and consistent feed streams of the raw materials which makes loss-in-weight feeders invaluable. Periodic hopper refill of the feeders, which is needed for continuous operation, can lead to inconsistent and poor feeding performance. This paper...
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Development of directly compressible powders via co-spray drying
Contributor(s):: Gonnissen, Y., Remon, J. P., Vervaet, C.
Continuous production of directly compressible powders was achieved by coprocessing acetaminophen and carbohydrates via spray drying. Binary and ternary powder mixtures containing drug substance and carbohydrates were prepared by co-spray drying and evaluated on spray drying processibility,...
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Continuous direct tablet compression: effects of impeller rotation rate, total feed rate and drug content on the tablet properties and drug release
Contributor(s):: Jarvinen, Maiju A., Paaso, Janne, Paavola, Marko, Leiviska, Kauko, Juuti, Mikko, Muzzio, Fernando, Jarvinen, Kristiina
Context: Continuous processing is becoming popular in the pharmaceutical industry for its cost and quality advantages. Objective: This study evaluated the mechanical properties, uniformity of dosage units and drug release from the tablets prepared by continuous direct compression process....