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1. Enabling intensification of multiphase chemical processes with additive manufacturing

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   09 Jun 2023 | Contributor(s):: McMillin, RE, Luxon, AR, Ferri, JK

   Fixed bed supports of various materials (metal, ceramic, polymer) and geometries are used to enhance the performance of many unit operations in chemical processes. Consider first metal and ceramic monolith support structures, which are typically extruded. Extruded monoliths contain regular,...

2. Controlling release from 3D printed medical devices using CLIP and drug-loaded liquid resins

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   09 Jun 2023 | Contributor(s):: Bloomquist, CJ, Mecham, MBParadzinsky, MD, Janusziewicz, R, Warner, SB, Luft, JC, Mecham, SJ, Wang, AZ, DeSimone, JM

   Mass customization along with the ability to generate designs using medical imaging data makes 3D printing an attractive method for the fabrication of patient-tailored drug and medical devices. Herein we describe the application of Continuous Liquid Interface Production (CLIP) as a method to...

3. Coupling hot melt extrusion and fused deposition modeling: Critical properties for successful performance

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   09 Jun 2023 | Contributor(s):: Bandari, Suresh, Nyavanandi, Dinesha, Dumpa, Nagireddy, Repka, Michael A.

   Interest in 3D printing for pharmaceutical applications has increased in recent years. Compared to other 3D printing techniques, hot melt extrusion (HME)-based fused deposition modeling (FDM) 3D printing has been the most extensively investigated for patient-focused dosage. HME technology can be...

4. Additive Layer Manufacturing of Catalytic Static Mixers for Continuous Flow Reactors

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   09 Jun 2023 | Contributor(s):: Hornung, CH, Singh, S, Saubern, S

   With a design guided by computational fluid dynamics (CFD), additively manufactured from base metals and coated with metal catalysts using cold spray technology or electroplating, catalytic static mixers are used to replace fixed bed columns in continuous flow reactors. We have shown their...

5. 3D Printed Reactors for Synthesis of Active Pharmaceutical Ingredients in Continuous Flow

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   09 Jun 2023 | Contributor(s):: Maier, MC, Valotta, AHiebler, K, Soritz, S, Gavric, K, Grabner, B, Gruber-Woelfler, H

   Advances in flow chemistry to produce active pharmaceutical ingredients (APIs) require performing reactions in tailor-made equipment as complexity of the planned setups increases. To react quickly and with low costs to these demanding reactions, additive manufacturing, also known as 3D printing,...