Process Development for Synthesizing the Cephalosporin Antibiotic Cefotaxime in Batch and Flow Mode
Contributor(s):: Pieper, Matthias, Kumpert, Mario, König, Burghard, Schleich, Herbert, Bayer, Thomas, Gröger, Harald
The pharmaceutically active substance cefotaxime, a commercial cephalosporin-type antibiotic, is accessible in an amide-bond-forming reaction from 7-aminocephalosporanic acid as the amine donor and nonactivated (Z)-(2-aminothiazol-4-yl)-methoxyiminoacetic acid as the acid component with...
Continuous Synthesis of Carbamates from CO2 and Amines
Contributor(s):: Stagel, Kristof, Bica-Schröder, Katharina, Lelo Laura
We present a novel approach for the continuous preparation of carbamates. The simple yet fast synthetic route relies on directly utilizing carbon dioxide and, in contrast with the literature-known methods, only employs 1,8-diazabicyclo[5.4.0]undec-7-ene as an additive. The applicable amines’...