A flow-based synthesis of telmisartan
Contributor(s):: Martin, Alex D., Siamaki, Ali R., Belecki, Katherine, Gupton, B. Frank
A highly efficient continuous synthesis has been developed for telmisartan, the active ingredient in the antihypertensive drug, Micardis. This synthetic route employs a convergent strategy that requires no intermediate purifications or solvent exchanges. The key step in the reaction scheme is a...