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Tags: antimalarial

Resources (1-2 of 2)

  1. Continuous synthesis of artemisinin-derived medicines

    24 Apr 2024 | Contributor(s):: Gilmore, Kerry, Kopetzki, Daniel, Lee, Ju Weon, Horváth, Zoltán, McQuade, D. Tyler, Seidel-Morgenstern, Andreas, Seeberger, Peter H.

    Described is a continuous, divergent synthesis system which is coupled to continuous purification and is capable of producing four anti-malarial APIs. The system is comprised of three linked reaction modules for photooxidation/cyclization, reduction, and derivatization. A fourth module couples...

  2. High-yielding continuous-flow synthesis of antimalarial drug hydroxychloroquine

    09 Jun 2023 | Contributor(s):: Yu, E, Mangunuru, HPRTelang, NS, Kong, CJ, Verghese, J, Gilliland, SE, Ahmad, S, Dominey, RN, Gupton, BF

    Numerous synthetic methods for the continuous preparation of fine chemicals and active pharmaceutical ingredients (API's) have been reported in recent years resulting in a dramatic improvement in process efficiencies. Herein we report a highly efficient continuous synthesis of the antimalarial...