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Continuous Flow Chemistry of Metal Mediated Carboxylation and α-Arylation Reactions
Contributor(s):: Venkatraman, Sripathy, Tweedie, Scott, McLaws, Mark, Lathbury, David
Utility of continuous flow chemistry in a carboxylation reaction and palladium-mediated α-arylation reaction is described. A two-step carboxylation reaction of an aryl group involving an anion formation, followed by quench with gaseous carbon dioxide was developed on small scale using HDPE tubes...
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Twin Screw Continuous Wet Granulation
Contributor(s):: Shah, Ankita V., Serajuddin, Abu T. M.
Granulation has become an integral part of the formulation of tablets. Wet granulation and roller compaction, which were developed over 50 years ago in the 1950s and 1960s, are still the most commonly used granulation methods in the pharmaceutical industry. However, these are batch processes and...
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How to Design and Implement Powder-to-Tablet Continuous Manufacturing Systems
Contributor(s):: Sarang Oka, Muzzio, Fernando
How to Design and Implement Powder-to-Tablet Continuous Manufacturing Systems provides a comprehensive overview on the considerations necessary for the design of continuous pharmaceutical manufacturing processes. The book covers both the theory and design of continuous processing of associated...
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Continuous Pharmaceutical Processing
Contributor(s):: Zoltan K Nagy, Arwa El Hagrasy, Jim Litster
Covers chemical engineering principles, regulatory aspects, primary and secondary manufacturing, process analytical technology and quality-by-design
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Continuous manufacturing of pharmaceuticals
Contributor(s):: Johannes Khinast, Jukka Rantanen
A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals.As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process...
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Cellulose Ethers for Extrusion Applications
Contributor(s):: Pinto, Elanor, Duerig, Thomas
Cellulose ethers have been used for years in developing oral dosage forms via batch processes such as direct compression and wet granulation. Recent advances in continuous manufacturing have brought about innovative technologies such as hot melt extrusion, melt extrusion granulation, and...