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Cellulose Ethers for Extrusion Applications

By Pinto, Elanor; Duerig, Thomas

Published on

Abstract

Cellulose ethers have been used for years in developing oral dosage forms via batch processes such as direct compression and wet granulation. Recent advances in continuous manufacturing have brought about innovative technologies such as hot melt extrusion, melt extrusion granulation, and continuous wet granulation. Hydroxypropylcellulose and ethylcellulose have advantageous thermal viscoelastic properties making them great polymers to use in extrusion applications for developing immediate and controlled release dosage forms. Hypromellose and its derivatives can be utilized to prevent recrystallization and for solubilization.

Journal

Melt Extrusion. AAPS Advances in the Pharmaceutical Sciences Series. Volume 9, 2013, 123-144

DOI

10.1007/978-1-4614-8432-5_5

Type of publication

Chapter Book

Affiliations

  • Ashland Specialty Chemical Co

Article Classification

Book chapter

Classification Areas

  • Oral solid dose
  • Material characterization

Tags