Cellulose Ethers for Extrusion Applications
Category
Published on CMKC
Abstract
Cellulose ethers have been used for years in developing oral dosage forms via batch processes such as direct compression and wet granulation. Recent advances in continuous manufacturing have brought about innovative technologies such as hot melt extrusion, melt extrusion granulation, and continuous wet granulation. Hydroxypropylcellulose and ethylcellulose have advantageous thermal viscoelastic properties making them great polymers to use in extrusion applications for developing immediate and controlled release dosage forms. Hypromellose and its derivatives can be utilized to prevent recrystallization and for solubilization.
Journal
Melt Extrusion. AAPS Advances in the Pharmaceutical Sciences Series. Volume 9, 2013, 123-144
DOI
10.1007/978-1-4614-8432-5_5
Type of publication
Chapter Book
Affiliations
- Ashland Specialty Chemical Co
Article Classification
Book chapter
Classification Areas
- Oral solid dose
- Material characterization