All Categories (1-3 of 3)

1. Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation

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   09 Jun 2023 | Contributor(s):: Patil, H, Tiwari, RV, Repka, MA

   Hot-melt extrusion (HME) is a promising technology for the production of new chemical entities in the developmental pipeline and for improving products already on the market. In drug discovery and development, industry estimates that more than 50% of active pharmaceutical ingredients currently...

2. Characterization of Amorphous Solid Dispersion of Pharmaceutical Compound with pH-Dependent Solubility Prepared by Continuous-Spray Granulator

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   09 Jun 2023 | Contributor(s):: Tanaka, R, Hattori, YHorie, Y, Kamada, H, Nagato, T, Otsuka, M

   A continuous-spray granulator (CTS-SGR) is a one-step granulation technology capable of using solutions or suspensions. The present Research Article objectives were, (1) to reduce the manufacturing operations for solid dosage formulations, (2) to make amorphous solid dispersion (ASD) granules...

3. Cellulose Ethers for Extrusion Applications

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   09 Jun 2023 | Contributor(s):: Pinto, Elanor, Duerig, Thomas

   Cellulose ethers have been used for years in developing oral dosage forms via batch processes such as direct compression and wet granulation. Recent advances in continuous manufacturing have brought about innovative technologies such as hot melt extrusion, melt extrusion granulation, and...