-
Advancing tablet lubrication: A systematic comparison of feed frame lubrication and internal lubrication
Peer-reviewed journal | 26 Jan 2024 | Contributor(s):: Jens Bartsch, Markus Thommes, Christopher Mathias, René Brands
For the continuous manufacturing of tablets, internal lubrication is often utilized. Here, lubricant is added to a pre-blend in an additional blending step. However, over-lubrication may occur, with a negative impact on the tablet quality. This study consequently focuses on the...
-
Simplified end-to-end continuous manufacturing by feeding API suspensions in twin-screw wet granulation
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Schmidt, A, de, Waard, HMoll, KP, Kleinebudde, P, Krumme, M
This study focussed on investigating the coupling of continuous manufacturing of drug substance and continuous manufacture of drug product. An important step in such an integrated end-to-end continuous manufacturing was envisioned by dosing the API as suspension into a twin-screw wet granulation...
-
Nondestructive measurements of the compact strength and the particle-size distribution after milling of roller compacted powders by near-infrared spectroscopy
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Gupta, A, Peck, GE, Miller, RW, Morris, KR
Compact strength and the particle-size distribution of milled roller compacted compacts were correlated to the slope of the best-fit line through near-infrared spectra for samples prepared under different roll speeds and feed rates. The above correlations were found to hold for compacts prepared...
-
Compaction properties of melt coated coarse drug particles
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Gren, T, Nystrom, C
Xylitol and stearic acid were applied onto the surfaces of coarse particles of paracetamol and acetylsalicylic acid by continuous multipurpose melt technology. The effect of melt coating on radial and axial tensile strength was studied and compared to that of dry mixing of paracetamol and...