All Categories (1-6 of 6)

1. Separation and Purification in the Continuous Synthesis of Fine Chemicals and Pharmaceuticals

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   09 Jun 2023 | Contributor(s):: O'Mahony, M, Ferguson, SStelzer, T, Myerson, A

   The use to both chemists and chemical engineers working in flow synthesis, this chapter provides a summary of separation and purification operations that can be applied to flow synthesis reaction streams. Both single and biphasic separations for the liquid phase are detailed. Separation and...

2. Modeling of pharmaceutical filtration and continuous integrated crystallization-filtration processes

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   09 Jun 2023 | Contributor(s):: Nagy, B, Szilagyi, BDomokos, A, Tacsi, K, Pataki, H, Marosi, G, Nagy, ZK

   As continuous manufacturing is evolving in the pharmaceutical industry, continuous filtration has emerged as a bottleneck for connecting the crystallization of the active pharmaceutical ingredient with the formulation of the final drug product. This work aims the modeling of filtration to improve...

3. Mathematical modeling and digital design of an intensified filtration-washing-drying unit for pharmaceutical continuous manufacturing

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   09 Jun 2023 | Contributor(s):: Destro, Francesco, Hur, Inyoung Wang, Vivian Abdi, Mesfin, Feng, Xin, Wood, Erin, Coleman, Simon, Firth, Paul, Barton, Alastair, Barolo, Massimiliano, Nagy, Zoltan K.

   This paper introduces a comprehensive mathematical model of a novel integrated filter-dryer carousel system, designed for continuously filtering, washing and drying a slurry stream into a crystals cake. The simulator includes models for dead-end filtration, cake washing and convective cake...

4. Development of Continuous Filtration in a Novel Continuous Filtration Carousel Integrated with Continuous Crystallization

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   09 Jun 2023 | Contributor(s):: Liu, Yiqing C., Domokos, András, Coleman, Simon, Firth, Paul, Nagy, Zoltan K.

   Pharmaceutical manufacturing has been largely carried out in batch mode, which has disadvantages such as batch-to-batch variations and difficult scale-up. As a result, the pharmaceutical industry is going through the paradigm shift to continuous manufacturing. Many unit operations have been...

5. Development of a Novel Continuous Filtration Unit for Pharmaceutical Process Development and Manufacturing

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   09 Jun 2023 | Contributor(s):: Ottoboni, S, Price, CJSteven, C, Meehan, E, Barton, A, Firth, P, Mitchell, A, Tahir, F

   The lack of a commercial laboratory, pilot and small manufacturing scale dead end continuous filtration and drying unit it is a significant gap in the development of continuous pharmaceutical manufacturing processes for new active pharmaceutical ingredients (APIs). To move small-scale...

6. Characterization of a Modular Continuous Vacuum Screw Filter for Small-Scale Solid-Liquid Separation of Suspensions

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   09 Jun 2023 | Contributor(s):: Steenweg, C, Seifert, AISchembecker, G, Wohlgemuth, K

   A key enabler for the future success of continuous manufacturing in pharmaceutical and fine chemical production processes is the control of product quality. Since approx. 90% of all small molecular active pharmaceutical ingredients produced involve a crystallization step, a holistic view on its...