All Categories (1-3 of 3)

1. Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry En Route to the Synthesis of Remdesivir

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   25 Jun 2024 | Contributor(s):: Vieira, Tiago, Stevens, Andrew C., Chtchemelinine, Andrei, Gao, Detian, Badalov, Pavel, Heumann, Lars

   The implementation of cyanation chemistry at manufacturing scales using batch equipment can be challenging because of the hazardous nature of the reagents employed and the tight control of reaction parameters, including cryogenic temperatures, that help to afford acceptable selectivity and...

2. A Two-Step Continuous-Flow Procedure towards Ribociclib

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   09 Jun 2023 | Contributor(s):: Pellegatti, L, Hafner, A, Sedelmeier, J

   This work describes the manufacturing of ribociclib following the concept of an end-to-end continuous-flow process. The active pharmaceutical ingredient (API) is produced in a two-step telescoped flow process with integrated in-line liquid-liquid extraction and semibatch crystallization.

3. 3D printing and continuous flow chemistry technology to advance pharmaceutical manufacturing in developing countries

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   09 Jun 2023 | Contributor(s):: Sagandira, CR, Siyawamwaya, M, Watts, P

   The realization of a downward spiralling of diseases in developing countries requires them to become self-sufficient in pharmaceutical products. One of the ways to meet this need is by boosting the local production of active pharmaceutical ingredients and embracing enabling technologies. Both 3D...