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18.117.106.78

A Two-Step Continuous-Flow Procedure towards Ribociclib

By Pellegatti, L; Hafner, A; Sedelmeier, J

View Resource (DOI)

Category

Peer-reviewed journal

Published on CMKC

Abstract

This work describes the manufacturing of ribociclib following the concept of an end-to-end continuous-flow process. The active pharmaceutical ingredient (API) is produced in a two-step telescoped flow process with integrated in-line liquid-liquid extraction and semibatch crystallization.

Journal

Journal of Flow Chemistry. Volume 6, 2016, 198-201

DOI

10.1556/1846.2016.00017

Type of publication

Peer-reviewed journal

Affiliations

  • Novartis Pharma AG

Article Classification

Research Article

Classification Areas

  • API

Tags

  1. API
  2. Continuous flow chemistry
  3. end-to-end manufacture
  4. in-line purification
  5. Research Article