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  1. A Two-Step Continuous-Flow Procedure towards Ribociclib

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    09 Jun 2023 | Contributor(s):: Pellegatti, L, Hafner, A, Sedelmeier, J

    This work describes the manufacturing of ribociclib following the concept of an end-to-end continuous-flow process. The active pharmaceutical ingredient (API) is produced in a two-step telescoped flow process with integrated in-line liquid-liquid extraction and semibatch crystallization.