Flow-oriented synthetic design in the continuous preparation of the aryl piperazine drug flibanserin
Contributor(s):: Bana, Péter, Szigetvári, Áron, Kóti, János, Éles, János, Greiner, István
An uninterrupted, four-step continuous-flow sequence was developed for the preparation of the aryl piperazine-type serotonin receptor modulator drug, flibanserin. The unprecedented route was designed for efficient operation in flow, consisting of heterogeneously catalyzed reductive amination...
A Two-Step Continuous-Flow Procedure towards Ribociclib
Contributor(s):: Pellegatti, L, Hafner, A, Sedelmeier, J
This work describes the manufacturing of ribociclib following the concept of an end-to-end continuous-flow process. The active pharmaceutical ingredient (API) is produced in a two-step telescoped flow process with integrated in-line liquid-liquid extraction and semibatch crystallization.