All Categories (1-4 of 4)

1. Semi-continuous multi-step synthesis of lamivudine

   out of 5 stars 

   Contributor(s):: Mandala, Devender, Chadaa, Sravanthi, Watts, Paul

   We report the first continuous flow synthesis of lamivudine, an antiretroviral drug used in the treatment of HIV/AIDS and hepatitis B. The key intermediate (5-acetoxy oxathiolane) was prepared by an integrated two step continuous flow process from L-menthyl glyoxalate hydrate in a single solvent,...

2. Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing

   out of 5 stars 

   | Contributor(s):: Zhang, Ping, Weeranoppanant, Nopphon, Thomas, Dale A., Tahara, Kohei, Stelzer, Torsten, Russell, Mary Grace, O'Mahony, Marcus, Myerson, Allan S., Lin, Hongkun, Kelly, Liam P., Jensen, Klavs F., Jamison, Timothy F., Dai, Chunhui, Cui, Yuqing, Briggs, Naomi, Beingessner, Rachel L., Adamo, Andrea

   As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy time-scale, we previously reported a refrigerator-sized continuous flow system for the on-demand production of essential medicines. Building...

3. Scalable and Sustainable Synthesis of Calcium Dobesilate via Integrated Five-Step Continuous-Flow Chemistry

   out of 5 stars 

   | Contributor(s):: Liu, Minjie, Wan, Li, Gao, Liang, Cheng, Dang, Jiang, Meifen, Chen, Fen-Er

   Calcium dobesilate is a widely prescribed veno-tonic drug in over 60 countries for treating chronic venous disease, diabetic retinopathy, and hemorrhoidal attack symptoms. Although two batchwise manufacturing routes to this treatment have been developed, the drawbacks, such as poor...

4. Laboratory of the future: a modular flow platform with multiple integrated PAT tools for multistep reactions

   out of 5 stars 

   | Contributor(s):: Sagmeister, Peter, Hone, Christopher, Williams, Jason D, Kappe, Oliver

   Currently, the monitoring of multistep continuous flow processes by multiple analytical sources is still seen as a resource intensive and specialized activity. In this article, the coupling of a modular microreactor platform with real-time monitoring by inline IR and NMR, in addition to online...