Currently, the monitoring of multistep continuous flow processes by multiple analytical sources is still seen as a resource intensive and specialized activity. In this article, the coupling of a modular microreactor platform with real-time monitoring by inline IR and NMR, in addition to online UPLC, is described. Using this platform, we rapidly generated experimental data (17 iterations in under 2 hours) to access information on the different chemical species at multiple points within the reactor and to generate process understanding. We highlight the application of the platform in the optimization of a multistep organolithium transformation. The optimized continuous flow conditions were demonstrated in a scale-out experiment with in-process monitoring to afford the desired product in 70% isolated yield and provided a throughput of 4.2 g h−1.

• Center for Continuous Synthesis and Processing (CCFLOW)
• University of Graz

• PAT
• API

1. API
2. Chemical species
3. Continuous-flow process
4. In-process monitoring
5. Multistep reactions
6. pat
7. Process understanding
8. Real-time monitoring
9. Research Article