Laboratory of the future: a modular flow platform with multiple integrated PAT tools for multistep reactions
Category
Published on CMKC
Abstract
Currently, the monitoring of multistep continuous flow processes by multiple analytical sources is still seen as a resource intensive and specialized activity. In this article, the coupling of a modular microreactor platform with real-time monitoring by inline IR and NMR, in addition to online UPLC, is described. Using this platform, we rapidly generated experimental data (17 iterations in under 2 hours) to access information on the different chemical species at multiple points within the reactor and to generate process understanding. We highlight the application of the platform in the optimization of a multistep organolithium transformation. The optimized continuous flow conditions were demonstrated in a scale-out experiment with in-process monitoring to afford the desired product in 70% isolated yield and provided a throughput of 4.2 g h−1.
Journal
DOI
Type of publication
Affiliations
- Center for Continuous Synthesis and Processing (CCFLOW)
- University of Graz
Article Classification
Classification Areas
- PAT
- API