Resources (1-5 of 5)

1. Development of Pilot-Scale Continuous Production of an LY2886721 Starting Material by Packed-Bed Hydrogenolysis

   0.0 out of 5 stars 

   25 Jun 2024 | Contributor(s):: Zaborenko, Nikolay, Linder, Ryan J., Braden, Timothy M., Campbell, Bradley M., Hansen, Marvin M., Johnson, Martin D.

   The design, development, and implementation of a pilot-scale continuous hydrogenolysis in a catalytic packed bed to generate a starting material is described. Control of a critical defluorination impurity under the reaction conditions has been achieved by reducing residence time inside the...

2. The Synthesis of Bromomethyltrifluoroborates through Continuous Flow Chemistry

   0.0 out of 5 stars 

   25 Jun 2024 | Contributor(s):: Broom, Toby, Hughes, Mark, Szczepankiewicz, Bruce G., Ace, Karl, Hagger, Ben, Lacking, Gary, Chima, Ranjit, Marchbank, Graeme, Alford, Gareth, Evans, Paul, Cunningham, Christopher, Roberts, John C., Perni, Robert B., Berry, Malcolm, Rutter, Andrew, Watson, Simon A

   A continuous flow process was developed for the synthesis of potassium bromomethyltrifluoroborate, a key precursor for Suzuki–Miyaura coupling reagents. The continuous flow process was used to produce potassium bromomethyltrifluoroborate on scales from grams to kilograms, and the successful...

3. Semi-continuous multi-step synthesis of lamivudine

   0.0 out of 5 stars 

   10 May 2024 | Contributor(s):: Mandala, Devender, Chadaa, Sravanthi, Watts, Paul

   We report the first continuous flow synthesis of lamivudine, an antiretroviral drug used in the treatment of HIV/AIDS and hepatitis B. The key intermediate (5-acetoxy oxathiolane) was prepared by an integrated two step continuous flow process from L-menthyl glyoxalate hydrate in a single solvent,...

4. Scalable and Sustainable Synthesis of Calcium Dobesilate via Integrated Five-Step Continuous-Flow Chemistry

   0.0 out of 5 stars 

   24 Apr 2024 | Contributor(s):: Liu, Minjie, Wan, Li, Gao, Liang, Cheng, Dang, Jiang, Meifen, Chen, Fen-Er

   Calcium dobesilate is a widely prescribed veno-tonic drug in over 60 countries for treating chronic venous disease, diabetic retinopathy, and hemorrhoidal attack symptoms. Although two batchwise manufacturing routes to this treatment have been developed, the drawbacks, such as poor...

5. Laboratory of the future: a modular flow platform with multiple integrated PAT tools for multistep reactions

   0.0 out of 5 stars 

   09 Jun 2023 | Contributor(s):: Sagmeister, Peter, Hone, Christopher, Williams, Jason D, Kappe, Oliver

   Currently, the monitoring of multistep continuous flow processes by multiple analytical sources is still seen as a resource intensive and specialized activity. In this article, the coupling of a modular microreactor platform with real-time monitoring by inline IR and NMR, in addition to online...