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1. Seven-Step Continuous Flow Synthesis of Linezolid Without Intermediate Purification

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   24 Apr 2024 | Contributor(s):: Russel, M. Grace, Jamison, Timothy F.

   Herein, the blockbuster antibacterial drug linezolid is synthesized from simple starting blocks by a convergent continuous flow sequence involving seven (7) chemical transformations. This is the highest total number of distinct reaction steps ever performed in continuous flow without conducting...

2. Application of Continuous Flow in Tazobactam Synthesis

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   24 Apr 2024 | Contributor(s):: Zhou, Shuhao, Xin, Yunting, Wang, Jiasheng, Wu, Chengjun, Sun, Tiemin

   Tazobactam is a β-lactamase inhibitor. In this work, a combination of continuous flow and batch experiments for the synthesis of tazobactam has been developed. The first three steps and the preparation of the peroxyacetic acid are continuously carried out in the microreactors, which improves the...