Seven-Step Continuous Flow Synthesis of Linezolid Without Intermediate Purification
Category
Published on CMKC
Abstract
Herein, the blockbuster antibacterial drug linezolid is synthesized from simple starting blocks by a convergent continuous flow sequence involving seven (7) chemical transformations. This is the highest total number of distinct reaction steps ever performed in continuous flow without conducting solvent exchanges or intermediate purification. Linezolid was obtained in 73 % isolated yield in a total residence time of 27 minutes, corresponding to a throughput of 816 mg h−1.
Journal
Angewandte Chemie International Edition. Volume 58, 2019, 7678-7681
DOI
10.1002/anie.201901814
Type of publication
Peer-reviewed journal
Affiliations
- Massachusetts Institute of Technology
Article Classification
Research Article
Classification Areas
- API