Peer-reviewed journal (1-5 of 5)

1. Twin screw granulation as a simple and efficient tool for continuous wet granulation

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   09 Jun 2023 | Contributor(s):: Keleb, EI, Vermeire, A, Vervaet, C, Remon, JP

   The modification of a twin screw extruder for continuous wet granulation was investigated. Modification of the extruder setup as well as the screw design allowed the continuous wet granulation of alpha-lactose monohydrate without the need of a wet sieving step. The robustness of twin screw...

2. System for Continuous Wet Granulation based on a High-shear Mixer

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   09 Jun 2023 | Contributor(s):: Chao, Chi, Steffens, Klaus-Juergen

   A new system for continuous wet granulation and drying, based on a modified high-shear-mixer is investigated using met-formine, paracetamole and ibuprofene as active ingredients. First experiments reveal the excellent shape and particle size distribution of the granules. Tabletting investigations...

3. Rolling phenomenon in twin screw granulation with controlled-release excipients

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   09 Jun 2023 | Contributor(s):: Thompson, M. R., O'Donnell, K. P.

   The developed knowledge regarding use of twin screw granulators for continuous wet granulation has been primarily limited to immediate release formulations in the literature. The present study highlights an issue previously unreported for wet granulation with twin screw extruders when using...

4. Real-time assessment of critical quality attributes of a continuous granulation process

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   09 Jun 2023 | Contributor(s):: Fonteyne, Margot, Vercruysse, Jurgen, Díaz, Damián Córdoba, Gildemyn, Delphine, Vervaet, Chris, Remon, Jean Paul, De Beer, Thomas

   There exists the intention to shift pharmaceutical manufacturing of solid dosage forms from traditional batch production towards continuous production. The currently applied conventional quality control systems, based on sampling and time-consuming off-line analyses in analytical laboratories,...

5. Foam granulation: new developments in pharmaceutical solid oral dosage forms using twin screw extrusion machinery

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   09 Jun 2023 | Contributor(s):: Thompson, M. R., Weatherley, S., Pukadyil, R. N., Sheskey, P. J.

   This paper investigates foam granulation in a twin screw extruder as a new continuous wet granulation technique for pharmaceutical powder drug formulations. Foamed aqueous binder has a reportedly lower soak-to-spread ratio than drop or spray liquid addition in batch granulation. This work...