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Continuous micro feeding and mixing of solid dosage forms under vibrational excitation
Peer-reviewed journal | 08 Oct 2024 | Contributor(s):: Haifeng Lu, Liang Zhang, Hui Du, Xiaolei Guo, Haifeng Liu
Continuous manufacturing has intrigued many researchers in the pharmaceutical industry in the post-COVID-19 world. We experimentally studied the discharge characteristics of pharmaceutical excipients under vibrational excitation. The successful accurate dosing and filling of powders at fill...
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Provoking an end-to-end continuous direct compression line with raw materials prone to segregation
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Lakio, Satu, Ervasti, Tuomas, Tajarobi, Pirjo, Wikstrom, Hakan, Fransson, Magnus, Karttunen, Anssi-Pekka, Ketolainen, Jarkko, Folestad, Staffan, Abrahmsen-Alami, Susanna, Korhonen, Ossi
Continuous manufacturing of solid oral dosage forms is promising for increasing the efficiency and quality of pharmaceutical production and products. In this study a whole train continuous direct compression (CDC) line has been provoked using challenging formulations typically prone to...
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Mixing Cell: a Device to Mimic Extent of Lubrication and Shear in Continuous Tubular Blenders
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Moghtadernejad, S, Escotet-Espinoz, AMS, Liu, ZJ, Schafer, E, Muzzio, F
Continuous manufacturing (CM) has clear potential for manufacturing solid oral dosages. It provides several advantages that may aid the manufacturing and quality of drug products. However, one of the main challenges of this technology is the relatively large amount of knowledge required and the...
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Investigation of the effect of impeller rotation rate, powder flow rate, and cohesion on powder flow behavior in a continuous blender using PEPT
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Portillo, PM, Vanarase, AU, Ingram, A, Seville, JK, Ierapetritou, MG, Muzzio, FJ
In this paper, we examine the movement of particles within a continuous powder mixer using PEPT (Positron Emission Particle Tracking). The benefit of the approach is that the particle movement along the vessel can be measured non-invasively. The effect of impeller rotation rate, powder flow rate,...
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Effects of processing parameters and blade patterns on continuous pharmaceutical powder mixing
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Osorio, JG, Muzzio, FJ
The present study summarizes the experimental characterization of a new continuous powder mixer (GCG-70 by Glatt (R)) using common pharmaceutical ingredients. The powder hold-up and residence time distribution were used to characterize the bulk behavior of the mixer as a function of impeller...
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Diminished segregation in continuous powder mixing
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Oka, S, Sahay, A, Meng, W, Muzzio, F
Binary powder mixtures with variable segregation tendencies were mixed in a tumbling batch blender and in a continuous convective tubular blender. The degree of homogeneity of the final blend obtained from the continuous blender was found to be much higher than that from the batch V-blender, for...
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Development of a continuous direct compression platform for low-dose drug products
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Van Snick, B, Holman, J, Vanhoorne, V, Kumar, A, De Beer, T, Remon, JP, Vervaet, C
In this work a continuous direct compression process was developed for a low-dosed drug product. Each unit operation of the GEA CDC-50 system was thoroughly investigated. This paper aimed to tackle the macroscopic and microscopic blend uniformity challenges inherently associated with continuous...
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Continuous mixing of powder mixtures with pharmaceutical process constraints
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Berthiaux, H, Marikh, K, Gatumel, C
While it would provide many advantages from many aspects, the application of continuous mixing processes to the pharmaceutical field is still in its infancy. In this paper we report results concerning the continuous mixing of nine ingredients (including three actives) that constitute a current...
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Continuous direct compression as manufacturing platform for sustained release tablets
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Vanhoorne, V, Holman, J., Cunningham, C., Kumar, A., Vercruysse, J., De Beer, T., Remon, J. P, Vervaet, C
This study presents a framework for process and product development on a continuous direct compression manufacturing platform. A challenging sustained release formulation with high content of a poorly flowing low density drug was selected. Two HPMC grades were evaluated as matrix former: standard...