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Near Infrared Method Development for a Continuous Manufacturing Blending Process
09 Jun 2023 | Contributor(s):: Colon, Yleana, Florian, Miguel, Acevedo, David, Mendez, Rafael, Romañach, Rodolfo
Purpose This study describes the validation of a near infrared spectroscopic method for monitoring a continuous manufacturing system. The achievement of this goal requires determining the near infrared (NIR) method’s accuracy, precision, obtaining an estimate of the sample volume analyzed, and...
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Experimental study of the stirring conditions taking place in a pilot plant continuous mixer of particulate solids
09 Jun 2023 | Contributor(s):: Marikh, K, Berthiaux, H, Mizonov, V, Barantsev, E
This work focuses on the characterisation and quantification of the stirring action that takes place inside a continuous mixer of particulate solids, under several operating conditions. Pure products, as well as 50% mass mixtures, are investigated to provide a basis for a better prediction of the...
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Effects of powder flow properties and shear environment on the performance of continuous mixing of pharmaceutical powders
09 Jun 2023 | Contributor(s):: Vanarase, AU, Osorio, JG, Muzzio, FJ
This paper focuses on two aspects of continuous powder mixing, namely characterizing the effects of material properties on the bulk powder flow behavior, and developing continuous blending strategies suitable for cohesive materials. The relative effects of process parameters and material...
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Effects of rotation rate, mixing angle, and cohesion in two continuous powder mixers-A statistical approach
09 Jun 2023 | Contributor(s):: Portillo, PM, Ierapetritou, MG, Muzzio, FJ
In this paper we examine the effect of rotation rate, mixing angle, and cohesion on the powder residence time and the content uniformity of the blend exiting from two continuous powder mixers. In addition, differences in mixing performance between the two blenders are examined. Analysis of...
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Dry Powder Mixing Is Feasible in Continuous Twin Screw Extruder: Towards Lean Extrusion Process for Oral Solid Dosage Manufacturing
09 Jun 2023 | Contributor(s):: Mateo-Ortiz, Daniel, Villanueva-Lopez, Vladimir, Muddu, Shashank Venkat, Doddridge, Gregory D., Alhasson, Dana, Dennis, Michael C.
Using discrete element method (DEM) modeling and near-infrared (NIR) spectroscopy, the feasibility of powder mixing in the initial pre-melting zones of a twin screw extruder using two independent feeders was studied. Previous work in the pharmaceutical and food industry has focused on mixing when...
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Development of a methodology to estimate error in the on-line measurements of blend uniformity in a continuous powder mixing process
09 Jun 2023 | Contributor(s):: Vanarase, Aditya, Järvinen, Maiju, Paaso, Janne, Muzzio, Fernando
In this paper, a multi-point fiber optic based NIR system was implemented to monitor API concentration at the discharge of a continuous mixer. The sample size being interrogated by NIR was determined by measuring the velocity of the powder on the chute, which allowed selection of the number of...
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Continuous direct tablet compression: effects of impeller rotation rate, total feed rate and drug content on the tablet properties and drug release
09 Jun 2023 | Contributor(s):: Jarvinen, Maiju A., Paaso, Janne, Paavola, Marko, Leiviska, Kauko, Juuti, Mikko, Muzzio, Fernando, Jarvinen, Kristiina
Context: Continuous processing is becoming popular in the pharmaceutical industry for its cost and quality advantages. Objective: This study evaluated the mechanical properties, uniformity of dosage units and drug release from the tablets prepared by continuous direct compression process....