Chapter Book (1-2 of 2)

1. Real-time feasible model-based crystal size and shape control of crystallization processes

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   09 Jun 2023 | Contributor(s):: Szilagyi, Botond, Nagy, Zoltan K.

   The simultaneous control of crystal size and shape is particularly important in fine chemical and pharmaceutical crystallization. These two quantities influence the dissolution rate and bioavailability of final drug products, and also contribute to the manufacturability and efficiency of...

2. Control of Batch and Continuous Crystallization Processes using Reinforcement Learning

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   09 Jun 2023 | Contributor(s):: Benyahia, Brahim, Anandan, Paul Danny Rielly, Chris Türkay, Metin, Gani, Rafiqul

   In crystallization processes, the control of particle size distribution, shape and purity are crucial to achieve the targeted critical quality attributes of the final drug product and meet the pharmaceutical regulatory requirements. This work presents novel optimal trajectory tracking control...