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Technoeconomic optimisation and comparative environmental impact evaluation of continuous crystallisation and antisolvent selection for artemisinin recovery
09 Jun 2023 | Contributor(s):: Jolliffe, HG, Gerogiorgis, DI
Systematic nonlinear optimisation is a valuable tool towards evaluating the performance of conceptual Continuous Pharmaceutical Manufacturing (CPM) flowsheets. This study considers total cost minimisation of multiple plausible design choices and eight candidate antisolvents for the continuous...
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Nucleation kinetics of paracetamolethanol solutions from metastable zone widths
09 Jun 2023 | Contributor(s):: Mitchell, Niall A., Frawley, Patrick J.
A study of the nucleation kinetics for a cooling crystallisation of paracetamolethanol solutions in a batch reactor is described in this paper. Metastable zone width (MSZW) experiments were conducted in order to estimate the nucleation kinetics of the system. Measured MSZWs can be affected by...
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Engineering of acetaminophen particle attributes using a wet milling crystallisation platform
09 Jun 2023 | Contributor(s):: Ahmed, B, Brown, CJMcGlone, T, Bowering, DL, Sefcik, J, Florence, AJ
Wet milling coupled with crystallisation has considerable potential to deliver enhanced control over particle attributes. The effect of process conditions and wet mill configuration on particle size, shape and surface energy has been investigated on acetaminophen using a seeded cooling...
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Computer Aided Design of Solvent Blends for Hybrid Cooling and Antisolvent Crystallization of Active Pharmaceutical Ingredients
09 Jun 2023 | Contributor(s):: Watson, OL, Jonuzaj, SMcGinty, J, Sefcik, J, Galindo, A, Jackson, G, Adjiman, CS
Choosing a solvent and an antisolvent for a new crystallization process is challenging due to the sheer number of possible solvent mixtures and the impact of solvent composition and crystallization temperature on process performance. To facilitate this choice, we present a general computer aided...