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Continuous Flow Total Synthesis of Rufinamide
Contributor(s):: Zhang, Ping, Russell, M. Grace, Jamison, Timothy F.
Small molecules bearing 1,2,3-triazole functionalities are important intermediates and pharmaceuticals. Common methods to access the triazole moiety generally require the generation and isolation of organic azide intermediates. Continuous flow synthesis provides the opportunity to synthesize and...
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A Continuous Flow Process for the Synthesis of Hymexazol
| Contributor(s):: Ma, Xin-peng, Chen, Jin-sha, Du, Xiao-hua
Hymexazol is an efficient and low-toxicity soil fungicide. In this work, a fully continuous flow process for the synthesis of hymexazol has been developed. This process begins with combining ethyl acetoacetate and hydroxylamine hydrochloride to form a hydroxamic acid intermediate. The reaction...
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Continuous Flow-Facilitated CB2 Agonist Synthesis, Part 2: Cyclization, Chlorination, and Amination
| Contributor(s):: Prieschl, Michael, Sagmeister, Peter, Moessner, Christian, Sedelmeier, Joerg, Williams, Jason D., Kappe, C. Oliver
A new route to the cannabinoid receptor type 2 agonist, RG7774, has been developed circumventing an alkylation with poor regioselectivity as the final step. In the new synthetic route, this side chain is incorporated from the beginning. In this article, the development of the final four...
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Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles
| Contributor(s):: Baumann M, Baxandale. I, Ley S, Smith G, Tranmer G
A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured to provide the maximum flexibility for...