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Solid forms of pharmaceuticals: Polymorphs, salts and cocrystals
09 Jun 2023 | Contributor(s):: Sarma, B, Chen, JHsi, HY, Myerson, AS
Control and selection of the properties of active pharmaceutical ingredients is a crucial part of the drug development process. One major part of this process is the selection of an appropriate solid form. This review will discuss three major types of crystalline solids, polymorphs, salts and...
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Reducing the mean size of API crystals by continuous manufacturing with product classification and recycle
09 Jun 2023 | Contributor(s):: Griffin, DW, Mellichamp, DA, Doherty, MF
A continuous crystallization process is proposed that can produce active pharmaceutical ingredients with a small mean size and narrow distribution. The process flowsheet consists of a new product classifier configuration where the large crystals from the classifier are recycled to a dissolver...
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Model-predictive design, control and optimization of pharmaceutical process
09 Jun 2023 | Contributor(s):: Muzzio, F, Singh, R Chaudhury, A Rogers, A Ramachandran, R, Ierapetritou, M
Applying model-predictive methods and a continuous process-control framework to a continuous tablet-manufacturing process. Currently, there is a high level of interest in the pharmaceutical industry in continuous-manufacturing strategies, integrated with online-monitoring tools, that are...
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Model-based computer-aided framework for design of process monitoring and analysis systems
09 Jun 2023 | Contributor(s):: Singh, Ravendra, Gernaey, Krist V, Gani, Rafiqul
In the manufacturing industry, for example, the pharmaceutical industry, a thorough understanding of the process is necessary in addition to a properly designed monitoring and analysis system (PAT system) to consistently obtain the desired end-product properties....
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Mechanistic modeling for systematic design and analysis of PAT systems
09 Jun 2023 | Contributor(s):: Singh, Ravendra, Samad, Noor Asma Fazli Abdul Gernaey, Krist V Woodley, John M, Gani, Rafiqul
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Designs of continuous-flow pharmaceutical crystallizers: developments and practice
09 Jun 2023 | Contributor(s):: Jiang, Mo, Braatz, Richard D.
Crystallization is an effective, low-cost purification & formulation process widely applied to pharmaceuticals and fine chemicals. This review describes recent advances in Research Article on lab-scale solution-based continuous crystallization, including (1) a 5-step general design procedure; (2)...