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Population balance model enabled digital design and uncertainty analysis framework for continuous crystallization of pharmaceuticals using an automated platform with full recycle and minimal material use
Peer-reviewed journal | 05 Sep 2024 | Contributor(s):: Wei-Lee Wu, Zoltan K. Nagy, Yash Barhate, Hemalatha Kilari
A systematic digital design framework for the development of a digital twin of a continuous crystallization process was presented using the model compound, diphenhydramine hydrochloride (DPH). The key features of the framework include operating space investigations, kinetic parameter estimation...
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End-to-end continuous flow synthesis and purification of diphenhydramine hydrochloride featuring atom economy, in-line separation, and flow of molten ammonium salts†
Peer-reviewed journal | 25 Jun 2024 | Contributor(s):: Snead, David R., Jamison, Timothy F.
A continuous end-to-end synthesis and purification of diphenhydramine hydrochloride featuring atom economy and waste minimization is described. Combining a 1 : 1 molar ratio of the two starting material streams (chlorodiphenylmethane and N,N-dimethylaminoethanol) in the absence of additional...
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Double-Track Electrochemical Green Approach for Simultaneous Dissolution Profiling of Naproxen Sodium and Diphenhydramine Hydrochloride
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Shehata, MA, Fawaz, EMAbd, El-Rahman, MK, Abdel-Moety, EM
Acquisition of the dissolution profiles of more than single active ingredient in a multi-analyte pharmaceutical formulation is a mandatory manufacturing practice that is dominated by utilization of the off-line separation-based chromatographic methods. This contribution adopts a new...