Modeling and Control of Roller Compaction for Pharmaceutical Manufacturing. Part I: Process Dynamics and Control Framework
09 Jun 2023 | Contributor(s):: Hsu, Shuo-Huan, Venkatasubramanian, Venkat, Reklaitis, Gintaras V.
We derive a dynamic model for roller compaction process based on Johanson’s rolling theory, which is used to predict the stress and density profiles during the compaction and the material balance equation which describes the roll gap change. The proposed model considers the relationship between...
Dynamic Plantwide Modeling, Uncertainty, and Sensitivity Analysis of a Pharmaceutical Upstream Synthesis: Ibuprofen Case Study
09 Jun 2023 | Contributor(s):: Montes, Frederico C.C., Gernaey, Krist, Sin, Gürkan
A dynamic plantwide model was developed for the synthesis of the active pharmaceutical ingredient (API) ibuprofen, following the Hoescht synthesis process. The kinetic parameters, reagents, products, and byproducts of the different reactions were adapted from literature, and the different process...