Biotransformation with whole microbial systems in a continuous flow reactor: resolution of (RS)-flurbiprofen using Aspergillus oryzae by direct esterification with ethanol in organic solvent
24 Apr 2024 | Contributor(s):: Tamborini, Lucia, Romano, Diego, Pinto, Andrea, Contente, Martina, Iannuzzi, Maria C., Conti, Paola, Molinari, Francesco
Cell-bound lipases of dry mycelium of Aspergillus oryzae were used in organic solvent for the resolution of racemic flurbiprofen by direct esterification with ethanol in a flow-chemistry reactor. Under flow conditions a significant reduction of the reaction time and an increase of the...