Cell-bound lipases of dry mycelium of Aspergillus oryzae were used in organic solvent for the resolution of racemic flurbiprofen by direct esterification with ethanol in a flow-chemistry reactor. Under flow conditions a significant reduction of the reaction time and an increase of the enantioselectivity were achieved compared to the batch mode. Moreover, the process was implemented by adding an in-line purification step integrated with the racemization of the unreacted flurbiprofen directly into a polymer-supported resin.

• la Nutrizione e l’Ambiente (DEFENS)
• Universitá degli Studi di Milano

• API

1. Amitriptyline
2. API
3. Biotransformation
4. enantioselectivity
5. Esterification
6. flow-chemistry reactor
7. flurbiprofen
8. Research Article