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1. Multiple Organolithium Generation in the Continuous Flow Synthesis of Amitriptyline

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   10 May 2024 | Contributor(s):: Kupracz, Lukas, Kirschning, Andreas

   A continuous flow protocol for the preparation of the tricyclic antidepressant (TCA) amitriptyline is reported. The advantages of flow chemistry when handling organometallic agents as well as when performing reaction with gases are demonstrated. Continuous multilithiation combined with...

2. Biotransformation with whole microbial systems in a continuous flow reactor: resolution of (RS)-flurbiprofen using Aspergillus oryzae by direct esterification with ethanol in organic solvent

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   24 Apr 2024 | Contributor(s):: Tamborini, Lucia, Romano, Diego, Pinto, Andrea, Contente, Martina, Iannuzzi, Maria C., Conti, Paola, Molinari, Francesco

   Cell-bound lipases of dry mycelium of Aspergillus oryzae were used in organic solvent for the resolution of racemic flurbiprofen by direct esterification with ethanol in a flow-chemistry reactor. Under flow conditions a significant reduction of the reaction time and an increase of the...