Skip to main content
Join CMKC members for a complimentary virtual event on December 10, 11am ET: CM MythBusters: https://bit.ly/3YXJynA. This is a fantastic opportunity to connect, collaborate, and debunk common myths about continuous manufacturing!
3.144.103.20

Multiple Organolithium Generation in the Continuous Flow Synthesis of Amitriptyline

By Kupracz, Lukas; Kirschning, Andreas

View Resource (DOI)

Category

Peer-reviewed journal

Published on

Abstract

A continuous flow protocol for the preparation of the tricyclic antidepressant (TCA) amitriptyline is reported. The advantages of flow chemistry when handling organometallic agents as well as when performing reaction with gases are demonstrated. Continuous multilithiation combined with carboxylation and the Parham cyclization, a Grignard addition and thermolytic water elimination by inductive heating are key features of the multistep protocol.

Journal

Advanced Synthesis & Catalysis. Volume 355, 2013, 3375-3380

DOI

10.1002/adsc.201300614

Type of publication

Peer-reviewed journal

Affiliations

  • Institut für Organische Chemie und Biomolekulares Wirkstoffzentrum (BMWZ) der Leibniz Universität Hannover,

Article Classification

Research Article

Classification Areas

  • API

Tags

  1. Amitriptyline
  2. API
  3. continuous flow synthesis
  4. Grignard addition
  5. inductive heating
  6. Parham cyclization
  7. Research Article
  8. tricyclic antidepressant (TCA)