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1. Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin

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   Contributor(s):: Pastre, Julio C., Murray, Philip R. D., Browne, Duncan L., Brancaglion, Guilherme A., Galaverna, Renan S., Pilli, Ronaldo A., Ley, Steven V.

   An integrated batch and continuous flow process has been developed for the gram-scale synthesis of goniothalamin. The synthetic route hinges upon a telescoped continuous flow Grignard addition followed by an acylation reaction capable of delivering a racemic goniothalamin precursor (16) (20.9 g...

2. Multiple Organolithium Generation in the Continuous Flow Synthesis of Amitriptyline

   out of 5 stars 

   Contributor(s):: Kupracz, Lukas, Kirschning, Andreas

   A continuous flow protocol for the preparation of the tricyclic antidepressant (TCA) amitriptyline is reported. The advantages of flow chemistry when handling organometallic agents as well as when performing reaction with gases are demonstrated. Continuous multilithiation combined with...