Multiple Organolithium Generation in the Continuous Flow Synthesis of Amitriptyline
Category
Published on
Abstract
A continuous flow protocol for the preparation of the tricyclic antidepressant (TCA) amitriptyline is reported. The advantages of flow chemistry when handling organometallic agents as well as when performing reaction with gases are demonstrated. Continuous multilithiation combined with carboxylation and the Parham cyclization, a Grignard addition and thermolytic water elimination by inductive heating are key features of the multistep protocol.
Journal
Advanced Synthesis & Catalysis. Volume 355, 2013, 3375-3380
DOI
10.1002/adsc.201300614
Type of publication
Peer-reviewed journal
Affiliations
- Institut für Organische Chemie und Biomolekulares Wirkstoffzentrum (BMWZ) der Leibniz Universität Hannover,
Article Classification
Research Article
Classification Areas
- API