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Tags: epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)

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Resources (1-2 of 2)

  1. Optimization and Scale-Up of the Continuous Flow Acetylation and Nitration of 4-Fluoro-2-methoxyaniline to Prepare a Key Building Block of Osimertinib

    out of 5 stars 

    Contributor(s):: Köckinger, Manuel, Wyler, Benjamin, Aellig, Christof, Roberge, Dominique M., Hone, Christopher A., Kappe, C. Oliver

    The development of a scalable telescoped continuous flow procedure for the acetylation and nitration of 4-fluoro-2-methoxyaniline is described. A subsequent batch deprotection then affords 4-fluoro-2-methoxy-5-nitroaniline, a key building block in the synthesis of osimertinib, a third-generation...

  2. Optimization and Scale-Up of the Continuous Flow Acetylation and Nitration of 4-Fluoro-2-methoxyaniline to Prepare a Key Building Block of Osimertinib

    out of 5 stars 

    Contributor(s):: Köckinger, Manuel, Wyler, Benjamin, Aellig, Christof, Roberge, Dominique M., Hone, Christopher A., Kappe, C. Oliver

    The development of a scalable telescoped continuous flow procedure for the acetylation and nitration of 4-fluoro-2-methoxyaniline is described. A subsequent batch deprotection then affords 4-fluoro-2-methoxy-5-nitroaniline, a key building block in the synthesis of osimertinib, a third-generation...