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1. An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

   out of 5 stars 

   Contributor(s):: Hopkin, Mark D., Baxendale, Ian R., Ley, Steven V.

   A flow-based route to imatinib, the API of Gleevec, was developed and the general procedure then used to generate a number of analogues which were screened for biological activity against Abl1. The flow synthesis required minimal manual intervention and was achieved despite the poor solubility of...

2. The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

   out of 5 stars 

   Contributor(s):: Baumann, M, Baxendale, IR

   The implementation of continuous flow processing as a key enabling technology has transformed the way we conduct chemistry and has expanded our synthetic capabilities. As a result many new preparative routes have been designed towards commercially relevant drug compounds achieving more efficient...