Dynamic Plantwide Modeling, Uncertainty, and Sensitivity Analysis of a Pharmaceutical Upstream Synthesis: Ibuprofen Case Study
Contributor(s):: Montes, Frederico C.C., Gernaey, Krist, Sin, Gürkan
A dynamic plantwide model was developed for the synthesis of the active pharmaceutical ingredient (API) ibuprofen, following the Hoescht synthesis process. The kinetic parameters, reagents, products, and byproducts of the different reactions were adapted from literature, and the different process...