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1. Tablet coating by injection molding technology - Optimization of coating formulation attributes and coating process parameters

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   Contributor(s):: Desai, Parind M., Puri, Vibha, Brancazio, David, Halkude, Bhakti S., Hartman, Jeremy E., Wahane, Aniket V., Martinez, Alexander R., Jensen, Keith D., Harinath, Eranda, Braatz, Richard D., Chun, Jung-Hoon, Trout, Bernhardt L.

   We developed and evaluated a solvent-free injection molding (IM) coating technology that could be suitable for continuous manufacturing via incorporation with IM tableting. Coating formulations (coating polymers and plasticizers) were prepared using hot-melt extrusion and screened via...

2. Integrated hot-melt extrusion - injection molding continuous tablet manufacturing platform: Effects of critical process parameters and formulation attributes on product robustness and dimensional stability

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   Contributor(s):: Desai, Parind M, Hogan, Rachael C., Brancazio, David, Puri, Vibha, Jensen, Keith D., Chun, Jung-Hoon, Myerson, Allan S., Trout, Bernhardt L.

   This study provides a framework for robust tablet development using an integrated hot-melt extrusion-injection molding (IM) continuous manufacturing platform. Griseofulvin, maltodextrin, xylitol and lactose were employed as drug, carrier, plasticizer and reinforcing agent respectively. A...

3. Development of Maltodextrin-Based Immediate-Release Tablets Using an Integrated Twin-Screw Hot-Melt Extrusion and Injection-Molding Continuous Manufacturing Process

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   Contributor(s):: Puri, Vibha, Brancazio, Dave, Desai, Parind M., Jensen, Keith D., Chun, Jung-Hoon, Myerson, Allan S., Trout, Bernhardt L.

   The combination of hot-melt extrusion and injection molding (HME-IM) is a promising process technology for continuous manufacturing of tablets. However, there has been limited Research Article on its application to formulate crystalline drug-containing immediate-release tablets. Furthermore,...