All Categories (1-6 of 6)

1. The Use of Cooling Crystallization in an Ionic Liquid System for the Purification of Pharmaceuticals

   out of 5 stars 

   Contributor(s):: Weber, CC, Kulkarni, SAKunov-Kruse, AJ, Rogers, RD, Myerson, AS

   The application of ionic liquids (ILs) as solvents is frequently discussed in the context of their tunability, with the potential to tailor the solvent system uniquely to the process being investigated. Instead, here we study the potential for a single IL, 1-ethyl-3-methylimidazohum...

2. The A Priori Design and Selection of Ionic Liquids as Solvents for Active Pharmaceutical Ingredients

   out of 5 stars 

   Contributor(s):: Kunov-Kruse, AJ, Weber, CCRogers, RD, Myerson, AS

   In this paper we derive a straightforward computational approach to predict the optimal ionic liquid (IL) solvent for a given compound, based on COSMO-RS calculations. These calculations were performed on 18 different active pharmaceutical ingredients (APIs) using a matrix of 210 hypothetical...

3. Separate mechanisms of ion oligomerization tune the physicochemical properties of n-butylammonium acetate: cation-base clusters vs. anion-acid dimers

   out of 5 stars 

   Contributor(s):: Berton, P, Kelley, SPWang, H, Myerson, AS, Rogers, RD

   We investigated the ability of the ions comprising protic ionic liquids to strongly interact with their neutral acid and base forms through the characterization of n-butylammonium acetate ([C4NH3][OAc]) in the presence of excess n-butylamine (C4NH2) or excess acetic acid (HOAc). The conjugate and...

4. Manipulation of ionic liquid anion-solute-antisolvent interactions for the purification of acetaminophen

   out of 5 stars 

   Contributor(s):: Weber, CC, Kunov-Kruse, AJRogers, RD, Myerson, AS

   Hydrogen bond donating cosolvents have been shown to significantly reduce the solubility of acetaminophen (AAP) in ionic liquids containing the acetate anion. Reduced solubility arises from competition for solvation by the acetate anion and can be used for the design of advanced separation...

5. Ionic liquids for energy, materials, and medicine

   out of 5 stars 

   Contributor(s):: Smiglak, M, Pringle, JMLu, X, Han, L, Zhang, S, Gao, H, MacFarlane, DR, Rogers, RD

   As highlighted by the recent ChemComm web themed issue on ionic liquids, this field continues to develop beyond the concept of interesting new solvents for application in the greening of the chemical industry. Here some current Research Article trends in the field will be discussed which show...

6. Ionic liquids in pharmaceutical industry: A systematic review on applications and future perspectives

   out of 5 stars 

   Contributor(s):: Zhuang, WC, Hachem, KBokov, D, Ansari, MJ, Nakhjiri, AT

   Ionic liquids (ILs) have demonstrated incredible potential of application in various industries such as pharmaceutics. Appropriate utilization of ILs in the pharmaceutical industry can be a great option to overcome the operational/functional challenges related to the use of traditional organic...