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Have you had challenges with CM adhesion/cohesion? Experts are discussing this topic in the Oral Solid Dosage Group,, broken out into the following key areas: conveying, feeding, transfer hoppers, and transition pipes. Learn from their experience by reading the full conversation here:

Tags: Loss-in-weight feeder

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  1. Advanced Manufacturing: An answer to supply chain woes?

    | Contributor(s):: Atul Dubey

    Advanced Manufacturing technologies (AMTs) in the pharmaceutical industry have increasingly gained attention in the last decade. Amongst the AMTs, continuous manufacturing (CM) has had the most prominent impact so far. International efforts to define manufacturing approaches, terms, regulatory...

  2. Influence of refilling on dosing accuracy of loss-in-weight powder feeders in continuous manufacturing

    | Contributor(s):: Jochen Thies, Peter Kleinebudde, Fabiola N. Santamaría Alvarez

    Continuous manufacturing is a novel concept to produce high quality drug products. The manufacture of solid dosage forms starts with the feeding of materials, which is consider a critical step because it could have a high influence on the quality of the final product. Therefore, this unit...

  3. New gravimetric dosing device for Continuous Manufacturing

    | Contributor(s):: VX management

    "So far, it is mainly Loss in Weight feeders (LIW) that are used for this purpose, especially in the pharmaceutical industry, as they can handle smaller flow rates accurately enough. The mechanical concept of these is decades old and despite miniaturisation and improvements at detail...

  4. Predicting feeder performance based on material flow properties

    | Contributor(s):: Yifan Wang, Benjamin J. Glasser, Fernando J. Muzzio 

    Purpose: Accurate and consistent delivery of materials by well-designed feeders ensures overall process stability. Importantly, feeding performance is strongly dependent on material flow properties. The purpose of this study is to develop a methodology that identifies predictive correlation...

  5. Powder composition monitoring in continuous pharmaceutical solid-dosage form manufacturing using state estimation-Proof of concept

    | Contributor(s):: Destro, Francesco, Munoz, Salvador Garcia, Bezzo, Fabrizio, Barolo, Massimiliano

    In continuous solid-dosage form manufacturing, the powder feeding system is responsible for supplying downstream the correct formulation of the drug product ingredients. The composition of the powder delivered by the feeding system is inferred from the measurements of powder mass flow from the...

  6. Influence of material properties and equipment configuration on loss-in-weight feeder performance for drug product continuous manufacture

    | Contributor(s):: Yadav, IK, Holman, JMeehan, E, Tahir, F, Khoo, J, Taylor, J, Benedetti, A, Aderinto, O, Bajwa, G

    A programme of work on continuous tablet manufacturing was completed as part of a UK based collaborative Research Article project (REMEDIES: RE-configuring MEDIcines End-to-end Supply) to evaluate the operating space of the continuous platform with respect to material properties. Loss-in-weight...

  7. Development of a Controlled Continuous Low-Dose Feeding Process

    | Contributor(s):: Fathollahi, Sara, Kruisz, Julia, Sacher, Stephan, Rehrl, Jakob, Escotet-Espinoza, M. Sebastian, DiNunzio, James, Glasser, Benjamin J., Khinast, Johannes G.

    This paper proposes a feed rate control strategy for a novel volumetric micro-feeder, which can accomplish low-dose feeding of pharmaceutical raw materials with significantly different powder properties. The developed feed-forward control strategy enables a constant feed rate with a minimum...

  8. Control strategy and methods for continuous direct compression processes

    | Contributor(s):: Suzuki, Yasuhiro, Sugiyama, Hirokazu, Kano, Manabu, Shimono, Ryutaro, Shimada, Gosuke, Furukawa, Ryoichi, Mano, Eichi, Motoyama, Keiichi, Koide, Tatsuo, Matsui, Yasuhiro, Kurasaki, Kazuki, Takayama, Issei, Hikage, Shunin, Katori, Noriko, Kikuchi, Masahiko, Sakai, Hiroshi, Matsuda, Yoshihiro

    We presented a control strategy for tablet manufacturing processes based on continuous direct compression. The work was conducted by the experts of pharmaceutical companies, machine suppliers, academia, and regulatory authority in Japan. Among different items in the process, the component ratio...

  9. Challenges in tracing material flow passing a loss-in-weight feeder in continuous manufacturing processes

    | Contributor(s):: Peterwitz, Moritz, Gerling, Sina, Schembecker, Gerhard

    Loss-in-weight feeders are an integral part of most continuous manufacturing processes, ensuring a constant mass flow. The feeders cause a significant degree of back-mixing in such lines. Understanding back-mixing is essential for the treatment of disturbances. However, feeders refilled...